Cannabinoids For Dermatological Disorders

REVIEW OF CANNABINOIDS FOR DERMATOLOGICAL DISORDERS

This week, KannAInsight features a comprehensive review by Tóth et al. (2019) on the promising role of endocannabinoids in skin-related diseases and disorders.

According to the authors, research has shown that cannabinoid signaling influences skin biology, exerting various biological effects in the skin. The current review examined the therapeutic potential of cannabinoids, as well as the possible limitations and side effects of such agents.

Various research models and some human evidence have demonstrated the therapeutic value of cannabinoids in several disorders and disease, including dryness, pigment disorders, wound healing, and inflammation-accompanied skin diseases such as psoriasis, allergic inflammation, or sunburn. Some data suggested the role of cannabinoid dysregulation in the development of the autoimmune disease, alopecia. Further, there are a number of papers in which cannabinoid signaling exerted anti-tumor activity in melanoma and non-melanoma skin cancer models.

Although, there are some potential side-effects associated with cannabinoid-based agents, such as unwanted hair growth or loss, itching, acne, skin dryness, increased/decreased skin pigmentation, and/or fibrosis, as well as concerns for cardiologic and psychotropic effects, the Tóth et al concluded that “cutaneous cannabinoid signaling promises to be a powerful tool” (p.34) for treating dermatological disorders.

Citation: Tóth KF, Ádám D, Bíró T, Oláh A. Cannabinoid signaling in the skin: Therapeutic potential of the “c(ut)annabinoid” system. Molecules. 2019 Mar 6; 24(5).