CBD for Patients with Fragile X Syndrome

This week, KannAInsight features a new study on the effects of CBD for symptoms associated with Fragile X syndrome.   

Fragile X syndrome (FXS) is one of the most common genetic developmental disabilities. Signs a child might have FXS include developmental delays (such as speech and language), learning disabilities, and social and behavioral problems. Autism spectrum disorder also occurs more frequently in individuals with FXS. There is no single treatment for FXS, but there are treatments that can help minimize the symptoms of the condition. In particular, an interesting new study suggests that individuals with FXS may benefit from cannabidiol (CBD).

In a small case series, researchers examined the effects of oral CBD-based products in one child and two adult FXS patients. Treatment with CBD resulted in continued improvement in a wide range of clinical parameters. For the adults, the positive benefits of CBD included increased use of language, increased engagement with others, improved sleep, and decreased anxiety. For the child, improvements were noted in eating behaviors, motor coordination, eye contact and social interactions, sleep, anxiety level, and language skills.

This study highlights the potential benefits of CBD for individuals with FXS. Earlier this year a patent was issued covering synthetic or purified CBD for the treatment of FXS. Clinical trials are currently underway to determine the long-term safety and efficacy of CBD in individuals with FXS.

Citation: Tartaglia N, Bonn-Miller M, Hagerman R. Treatment of Fragile X Syndrome with cannabidiol: A case series study and brief review of the literature. Cannabis Cannabinoid Res. 2019 Mar 13; 4(1): 3-9.

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