This week, KannAInsight features a new study on CBD and anxiety relief.
Unlike THC, CBD is not associated with feelings of intoxication or a “high”. For this reason, the therapeutic potential of CBD is being explored for a number of indications, including anxiety disorders. Indeed, several studies suggest potential benefits of CBD for generalized anxiety, social anxiety, post-traumatic stress disorder, and even anxiety-induced insomnia.
In a recent study, the anxiolytic effects of CBD were studied in healthy individuals. Briefly, the acute effects of CBD (placebo, 150mg, 300mg, 600mg capsules) were tested in individuals performing a simulated public speaking test. Immediately after treatment, the participants were given 2 minutes to prepare a 4-minute speech that they presented in front of a camera while viewing their image on TV. Anxiety levels were measured before, during, and after the speech.
Results indicated that a single, acute dose of CBD decreased anxiety. Specifically, compared to placebo, pretreatment with 300 mg of CBD significantly reduced anxiety during the speech. No significant differences were observed between groups receiving placebo, 150 mg, or 600 mg.
Although these results are promising, they also suggest that CBD may have a narrow therapeutic window. Therefore, additional dose-response studies in clinical settings are necessary to establish safe and efficacious dosing of CBD for long-term use in individuals with anxiety disorders.
Citation: Linares IM, Zuardi AW, Pereira LC, Queiroz RH, Mechoulam R, Guimarães FS, Crippa JA. Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test. Braz J Psychiatry. 2019 Jan-Feb;41 (1): 9-14.
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